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Informatics Research Seminar: Ascertaining Death and Hospitalization Endpoints– The TRANSFORM-HF Experience
November 13 @ 4:00 pm - 5:00 pm EST
Speaker: Eric Eisenstein, DBA
Presented from Duke
Broadcast Link: Seminar
At Duke, all seminars live or broadcast will be held in Hock Auditorium from 4-5 pm.
Pragmatic clinical trials frequently rely upon information collected for other purposes (e.g., patient reported outcomes, health records and medical claims). This presentation will review and evaluate the different data sources that are available for ascertaining death and hospitalization endpoints in clinical research studies. Typically, a single data source is insufficient for obtaining complete death and hospitalization information. This leads to the creation of hybrid data collection strategies. TRANSFORM-HF’s death and hospitalization endpoint identification and validation procedures will be reviewed as an example of how multiple data collection methods can be used to obtain more complete data coverage in a pragmatic clinical trial.
Dr. Eisenstein’s primary research interest is the use of information technologies to simplify clinical trial operations and reduce research costs. This has included the evaluation of four population-based studies that used asynchronous decision support to improve care coordination for Medicaid patients. He is also involved with several efforts to evaluate the feasibility of eSource (direct data capture from site electronic health records to clinical trial databases). Currently, he is Data Coordinating Center Co-PI for the National Heart, Lung, and Blood Institute sponsored TRANSFORM-HF clinical trial. This 6000 patient heart failure pragmatic trial is using novel information technology strategies to simplify clinical trial design, improve operations and reduce costs.