Improving the Public Interface for Use of Aggregate Data in ClinicalTrials.gov

 

 

by Asba Tasneem

ClinicalTrials.gov is a registry of human clinical research studies hosted by the U.S. National Institutes of Health, through the National Library of Medicine. The purpose of ClinicalTrials.gov is to provide a central resource for those seeking information on individual clinical research projects and to increase visibility of human subjects’ research. A Duke project team of principal investigators from several therapeutic areas and staff
members from DCRI-CRI, DCTI-IT, DCRI-CDM, DCRI-Communications, and CTTI, downloaded publicly available registry data from ClinicalTrials.gov and developed a restructured and reformatted relational database under the Clinical Trials Transformation Initiative (CTTI) grant. This is referred to as the database for Aggregate Analysis of ClincalTrials.gov (AACT). 

Recently, NLM made the results dataset available through public download. In 2013, the Duke team extended the AACT database to include the results dataset. An updated version of the AACT database is now available on the CTTI website. The latest version of AACT contains data downloaded from ClinicalTrials.gov on September 27, 2012 and includes study registration fields, basic results fields, and adverse events reporting fields. This is the first attempt to re-structure basic results and adverse events datasets from ClinicalTrials.gov for the purpose of aggregate analysis.

This effort is led by Robert Califf, MD.